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Additional costs: according to the mayo clinic , a doctor may prescribe an oral corticosteroid, such as prednisone (about $20-$. Corticosteroid cream · corticosteroid pills or liquid · corticosteroid shot (injection). Poison ivy rash is an allergic reaction to poison ivy. Using calamine lotion or corticosteroid cream on the skin. For mild rashes that are not on the face or private areas, dr. Riech recommends over-the-counter topical steroids like hydrocortisone to treat. Calamine lotion is particularly helpful at relieving any itching on your poison oak or poison ivy rash. Hydrocortisone cream is another good option to consider. Cool compresses over the rash · oatmeal baths · calamine lotion, although this shouldn't be applied to the face or genitals · over-the-. You can take one of the following drugs for severe itching: diphenhydramine (benadryl). Some home care medicines applied to the skin can make the rash worse, rather than help. These include topical antihistamines like benadryl cream, topical. Apply topical 1 percent hydrocortisone cream to decrease the inflammation. Otc cortisone creams and calamine lotion can help ease some of the itchiness of a poison ivy rash. Follow the label directions when applying. In addition to treatments from their pediatrician, some parents also try an otc poison ivy medication, such as ivarest medicated cream, ivystat, In addition to treatments from their pediatrician, some parents also try an otc poison ivy medication, such as ivarest medicated cream, ivystat,. This rash may appear anywhere on your body. Otc medications and creams do not provide much relief. With early treatment, prescription oral steroid medication. Contact dermatitis, particularly from toxidendron foliage (poison ivy, oak, and sumac), is a common complaint in primary care offices. Your doctor may treat your rash with prescription corticosteroid pills, creams, or shots. Poison ivy has oil called urushiol. 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